
With the news that MotoAmerica is headed to Daytona International Speedway in March of 2022 for the Daytona 200, we decided the perfect way to build excitement for the event would be to start digging through the history books and memory banks. Since Paul Carruthers is literally as old as the Speedway itself and covered almost 30 Daytona 200s as a journalist while working at Cycle News, it was a no-brainer that it would be him who would take on the task of trying to recall the good and the bad. And since we are the home of the AMA Superbike Series, we figured we’d have him start his look back with the 1985 Daytona 200 – the first of the 200s to feature Superbikes – and go from there. This week, we focus on the 1991, 1992 and 1993 Daytona 200s.
1991
Winner: Miguel Duhamel, Honda RC30
Miguel Duhamel didn’t even have plans to compete in the Daytona 200 in 1991 much less winning it. Drafted in as replacement for the injured Randy Renfrow, Duhamel made the most of the opportunity given to him by Commonwealth Honda team owner Martin Adams as he put the Camel-backed Honda out front for 32 of the 57 laps and stormed to a 10.290-second victory.

The Turning Point: Fast By Ferracci’s Doug Polen was the fastest of the fast all week at Daytona International Speedway, but the polesitter was out of the race on the opening lap of the 200 when his Ducati threw a chain. Polen earned pole position with his 1:53.638/112.779 mph lap on Wednesday of Bike Week and it was the first for Ducati at Daytona and the first pole position for a non-Japanese motorcycle since England’s Paul Smart put his Triumph on pole in 1971.
Newsworthy: Duhamel beat the Vance & Hines Yamahas of Jamie James and Thomas Stevens. Duhamel’s teammate Rich Arnaiz was fourth, despite riding with a broken finger and a badly battered left hand, with Muzzy Kawasaki’s Scott Russell finishing fifth.
Six riders took a turn at leading the 200, helping make the 50th running of the race one of the most exciting in recent memory. In addition to Duhamel, James, Tom Kipp, Steven and Arnaiz all led at some point in the race.
Duhamel’s winning average speed was only 93.471 mph as some 13 laps were run behind a pace car and under caution flags.
Duhamel not only won the Daytona 200, but he also came out of the 600cc Supersport race with a victory. “It feels great to win Daytona,” the 23-year-old French Canadian said. “The names that come to your head are Freddie Spencer and Kevin (Schwantz) and those guys. I can’t believe I’m here. I can’t believe I won this race. This is the greatest feeling you can have.”

1992
Winner: Scott Russell, Kawasaki ZX-7R
The man who would go on to be known simply as “Mr. Daytona” won his first Daytona 200 in 1992, the Georgian winning a near photo finish over Fast By Ferracci’s World Superbike Champion Doug Polen. Russell won the race with a record average speed of 110.669 mph to best Polen by just .182 of a second.
The Turning Point: As has been the case in a zillion races at Daytona International Speedway, the race came down to the final lap with Russell following Polen through the chicane and setting himself up for a slingshot pass just before the finish line.
Newsworthy: As the 110.669 mph average speed shows, the pace car was never needed in the 1992 edition of the Daytona 200.
The crowd for the 51st running of the Daytona 200 was estimated to be 40,000.

With Polen finishing a close second to Russell, third place went to another Georgian – Mike Smith – in what was his debut race on the Camel-backed Commonwealth Honda RC30.
“I knew coming into this race that I could win if everything went well,” Russell said. “I’m glad we put on a show for the fans and for the finish to be that close. It was pretty exciting.”
Doug Polen smashed the track record at Daytona during Wednesday’s qualifying with the Texan lapping at 1:50.388 on the 3.56-mile road course. His lap was three seconds faster than his pole setting lap from the year before. His qualifying session was cut short when he crashed the Fast By Ferracci Ducati in turn one, escaping without injury.
An 18-year-old Texan by the name of Colin Edwards won the International Lightweight (250cc) race in his Bike Week debut at Daytona. Third place went to another 18-year-old making his AMA professional debut – Kenny Roberts Jr. on the Wayne Rainey Racing Otsuka Electronics Yamaha.
Miguel Duhamel, the winner of the 1991 Daytona 200, was contesting the 500cc World Championship and didn’t compete at Daytona in 1992. Although Miguel Duhamel wasn’t racing at Daytona, his father Yvon certainly was. The elder Duhamel won the BMW-sponsored Battle of the Legends race, which was held in conjunction with the AHRMA Classics Day.

1993
Winner: Eddie Lawson, Yamaha FZR750RR OW-01
Four-time 500cc World Champion Eddie Lawson came out of his brief retirement to win the 52nd running of the Daytona 200, the Californian besting 1992 Daytona 200 winner Scott Russell on the run to the flag by just .051 of a second on his Vance & Hines Yamaha FZR750RR OW-01.
The Turning Point: For the first time in Daytona 200 history, the leaders actually stopped for new tires on three occasions. As it turns out, the first four finishers all needed three sets of rear tires to go the distance at the pace they were running. When Lawson pitted for a third rear tire, it looked like the race would go to Russell as he led by 36 seconds on the 49th of 57 laps. But just when it appeared Lawson’s hopes were dashed, Russell was also forced to get a third rear tire.
Newsworthy: With Lawson barely beating Russell for the victory, third place went to Miguel Duhamel on the second Muzzy Kawasaki. Duhamel’s third place meant that all three of the riders in Victory Lane were former winners of the Daytona 200. Lawson previously won in 1986, Duhamel won in 1991 and Russell had tasted victory in 1992.
Lawson pleaded ignorance when asked what Dunlop rear tire had been fitted on their bikes in their final stops. “I don’t know,” Lawson deadpanned. “It had yellow letters on it, and it was black.”

The race was marred by the death of AMA road racing fixture Jimmy Adamo, who suffered his fatal crash on the sixth lap of the 200. The 36-year-old’s death was just the fourth motorcycle-racing-related fatality in Daytona International Speedway history.
Following his second-place finish in 200, Russell was slated to head to Europe to contest the 1993 World Superbike Championship.
Russell smashed Doug Polen’s one-year-old lap record at Daytona when he ripped off a 1:50.194 lap in Thursday’s qualifying session. Polen ended up qualifying second for the race while Lawson’s Yamaha blew an engine during qualifying, forcing him to start on the back row for his Twin 50 qualifier.
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Diflucan is not recommended for treatment of Pneumocystis jirovecii pneumonia.
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Diflucan is not active against the dimorphic fungus Blastomyces dermatitidis.
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Used off-label for prolonged periods in certain endemic fungal infections.
Diflucan is available as a branded product and multiple generic equivalents.
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Transient, asymptomatic liver enzyme spikes are common and often do not require discontinuation.
Diflucan loading doses are used to achieve therapeutic levels rapidly in serious infections.
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Diflucan is often used for esophageal candidiasis in immunocompromised hosts.
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Multiple drug interactions stem from its inhibition of human CYP2C9 and CYP3A4.
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Often the initial antifungal encountered by medical students, establishing the azole class.
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Diflucan may be used for step-down therapy after initial echinocandin treatment for candidemia.
Diflucan is ineffective against Candida auris, a major multidrug-resistant pathogen.
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Diflucan can be used for prolonged periods in certain endemic mycoses.
Headache and gastrointestinal disturbances are the most frequently reported adverse events.
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Penetrates well into skin, nails, and blister fluid, supporting its use in dermatology.
Diflucan is not first-line for invasive aspergillosis under any circumstances.
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Diflucan should be avoided in patients with known hypersensitivity to other azoles.
Has some activity against Paracoccidioides brasiliensis.
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May unmask or exacerbate cutaneous lupus erythematosus.
Fluconazole inhibits fungal cytochrome P450 14a-demethylase, disrupting ergosterol synthesis.
Diflucan can cause taste distortion (dysgeusia) as a side effect.
Diflucan may have in vitro synergy with flucytosine against some Candida species.
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Its water solubility is a distinct advantage over older imidazole antifungals.
Diflucan has a well-established role in treating fungal keratitis caused by susceptible yeasts.
Transient, asymptomatic liver enzyme spikes are common and often do not require discontinuation.
Serves as a benchmark for in vitro susceptibility testing of newer antifungals.
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May significantly increase cyclosporine and tacrolimus levels, requiring close monitoring.
Excellent CSF penetration makes it a mainstay for cryptococcal meningitis suppression.
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Diflucan is a Schedule H/P drug in many countries, requiring a prescription.
Diflucan is ineffective against Fusarium and Scedosporium species.
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Diflucan is a foundational drug that exemplifies the principles of targeted antimicrobial therapy.
Diflucan can be used for prolonged periods in certain endemic mycoses.
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Diflucan may have in vitro synergy with flucytosine against some Candida species.
Liver enzyme elevation is the most common laboratory abnormality observed.
Therapeutic success relies heavily on host immune status and source control.
Resistance to Diflucan is a growing concern, particularly with Candida glabrata and krusei.
Concurrent use with statins metabolized by CYP3A4 increases risk of myopathy/rhabdomyolysis.
Diflucan is the prototypical agent for understanding azole antifungal resistance mechanisms.
“Fluconazole-refractory” candidiasis is a specific clinical entity in advanced AIDS.
Not reliably effective in fungal endocarditis, where fungicidal therapy is preferred.
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Diflucan may have in vitro synergy with flucytosine against some Candida species.
Generic fluconazole has made Diflucan’s benefits accessible at a lower cost.
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Its high selectivity for fungal enzymes over human ones is key to its relatively low toxicity.
Diflucan is often the first systemic antifungal agents that clinicians learn to use.
Hepatotoxicity, while rare, is a serious potential adverse effect of Diflucan.
Protein binding is relatively low (~12), contributing to good tissue distribution.
Emergence of resistance while on therapy necessitates repeat culture and susceptibility.
Diflucan is excreted in human milk, requiring careful risk-benefit analysis during lactation.
The development of Candida auris resistance has further limited its empirical utility.
Can cause taste distortion (dysgeusia) in some patients.
Diflucan is a foundational drug that exemplifies the principles of targeted antimicrobial therapy.
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Can be used for chronic suppressive therapy in recurrent mucosal candidiasis.
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Excellent CSF penetration makes it a mainstay for cryptococcal meningitis suppression.
May unmask or exacerbate cutaneous lupus erythematosus.
Diflucan dosing in continuous renal replacement therapy must account for effluent rate.
Diflucan is used in veterinary medicine for analogous fungal infections.
The development of Candida auris resistance has further limited its empirical utility.
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Therapeutic drug monitoring is not routinely required but can be useful in specific scenarios.
Diflucan’s role has been defined by large, randomized controlled trials in HIV and ICU populations.
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Diflucan is used for chronic suppression in patients with recurrent mucosal infections.